The action gets underway on Friday night when Romania vs Italy in Bucharest before France take on Japan and Ireland collide with New Zealand on Saturday morning.
Ange Capuozzo starts for Italy against Romania on Friday night as the full-back looks to back up his memorable match-winning assist against Wales in the 2022 Guinness Six Nations.
Capuozzo is joined in the back three by Pierre Bruno and Edoardo Padovani, with the latter named as captain after finishing off the move started by the 23-year-old to beat Wales.
Marco Zanon and Tommaso Menoncello form the midfield partnership while the backline is completed by Tommy Allan and uncapped Alessandro Garbisi, the brother of Paolo.
When is Romania vs Italy on and what time does it start?
Romania vs Italy Rugby will take place on Friday 1st July, 2022 – 19:00 (UK)
Where is Romania vs Italy taking place?
Romania vs Italy will take place at Stadionul National Arcul de Triumf in Bucharest, Romania
Where can I get tickets for Romania vs Italy?
Check each nation’s official Rugby Union website for the latest ticket information
What channel is Romania vs Italy on in the UK?
Romania vs Italy will not be televised live in the UK
Where can I stream Romania vs Italy Rugby in the UK?
Romania vs Italy cannot be streamed live in the UK
Ivan Nemer, Gianmarco Lucchesi and Simone Ferrari pack down together upfront, with Niccolò Cannone and Marco Fuser behind them in the engine room as the lock combination.
The starting line-up is completed by a back-row of Federico Ruzza, Manuel Zuliani and To a Halafihi, while Kieran Crowley has also named a powerful bench that includes Giacomo Nicotera, Cherif Traore, Ion Neculai, David Sisi and Michele Lamaro.
Paolo Garbisi, who only recently joined the group after winning the Top 14 title with Montpellier, also provides back-up along with Renato Giammarioli and Manfredi Albanese.
ITALY: 15 Ange Capuozzo, 14 Edoardo Padovani (C), 13 Tommaso Menoncello, 12 Marco Zanon, 11 Pierre Bruno, 10 Tommaso Allan, 9 Alessandro Garbisi; 1 Ivan Nemer, 2 Gianmarco Lucchesi, 3 Simone Ferrari, 4 Niccolò Cannone, 5 Marco Fuser, 6 Federico Ruzza, 7 Manuel Zuliani, 8 Toa Halafihi
REPLACEMENTS: 16 Giacomo Nicotera, 17 Cherif Traore, 18 Ion Neculai, 19 David Sisi, 20 Michele Lamaro, 21 Renato Giammarioli, 22 Manfredi Albanese, 23 Paolo Garbisi